European Journal of Pharmaceutics and Biopharmaceutics
Volume 69, Issue 2, June 2008, Pages 640-647
Research paper
Rationale for ibuprofen co-administration with antacids: Potential interaction mechanisms affecting drug absorption
Author links open overlay panelJelenaParojčićaOwen I.Corriganb
https://doi.org/10.1016/j.ejpb.2008.01.001
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Abstract
Ibuprofen is a widely used NSAID which is often co-administered with antacids because of its gastro-irritant effects. Literature data suggest that antacid interactions may increase or decrease the drug’s absorption rate and onset of action and that the interaction may be formulation specific. In the present study, literature data on ibuprofen absorption were evaluated in order to gain insight into the nature of the in vivo effect. Solubility determinations in reactive media containing magnesium or aluminium and dissolution studies in the presence of antacid suspension were performed in an attempt to simulate in vitro the effects observed in vivo. The results obtained indicate that magnesium hydroxide enhances ibuprofen solubility, dissolution and bioavailability, while aluminium hydroxide has a retarding effect.