The Democratic messaging group Future Majority in May released a deck identifying areas where Republicans hold an advantage:

Of the issues polled, “defunding the police,” “open borders” and “reparations for slavery” were by far the biggest turnoffs for both independents and voters in general.
Republicans bested Democrats on jobs and the economy, gun rights, and “keeping you and your family safe.”
The poll, Future Majority wrote in its report on the findings, “shows voters, especially Independents, believe Democrats overspend.” //

Of course, Republicans could screw all this up, whether it’s by folding to Democrats on policy or focusing on issues that don’t move the needle such as making everything about the 2020 election. If the GOP is going to win in 2022, they have to remain laser-focused on the issues that win elections. The time to worry about investigations and other issues like that is after retaking power because if they don’t, they won’t be able to move on any of that stuff anyway.